An ethanol extract of Poria cocos inhibits the proliferation of non-small cell lung cancer A549 cells via the mitochondria-mediated caspase activation pathway

An ethanol extract of Poria cocos inhibits the proliferation of non-small cell lung cancer A549 cells via the mitochondria-mediated caspase activation pathway

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Poria cocos, a food ingredient and a traditional Chinese medicine, is a fungus commonly used in eastern countries.It exhibits diuretic, anti-inflammatory, immunomodulatory and anti-hyperglycaemic functions.In addition, the polysaccharide and triterpenoid components isolated from P.

cocos exhibit anti-tumour effects in a number of cancer cell lines.Here, an extract of P.cocos, designated H287, was evaluated for its anti-lung cancer potential.

H287 trailmaster challenger 200x induced apoptosis in A549 cells via the mitochondria-mediated caspase activation pathway, as demonstrated by here the loss of mitochondria outer membrane potential, release of cytochrome c into the cytosol, and the cleavage of procapsase-9 to caspase-9.Further analyses suggest that tumulosic acid, one of the triterpenoids present in H287, is responsible for the cytotoxic function of H287.H287 may potentially serve as a dietary supplement or functional food ingredient for patients suffering from non-small cell lung cancers.